Can Priapism Damage be Reversed is a rare but serious condition characterized by a prolonged and often painful erection that lasts for more than four hours and is not associated with sexual activity or arousal. While erectile dysfunction (ED) treatments, especially certain medications, can sometimes increase the risk of priapism, it’s important to understand the specific risks associated with each treatment and how to manage them. While these medications are generally safe and effective, priapism is a known, albeit rare, side effect. It can occur if the drug causes prolonged engorgement of the penis that doesn’t subside.